Trauma may be linked to every setback...

TBI is linked with homelessness:

Almost half of homeless men had traumatic brain injury in their lifetime:

Brain Injury is linked with Cognitive Problems, and in my mind, this strongly correlates with all sorts of problems: social, economic, etc.

There's a connection between trauma and addiction and you'll be surprised by how it effects your life. One of authors of this article, Jo Harvey, has an amazing TedTalk about it here

I believe trauma is behind all of the behaviors we do that habitually, tragically, and consistently, create negative consequences. I believe Brain Trauma specifically, exacerbates other kinds of trauma.